Understanding probiotic bacterial growth

Trillions of microbes live within us in an ever-changing population that has profound impacts on our health. Even in healthy individuals, our microbiomes are dynamic communities comprising both beneficial commensal organisms and harmful opportunistic pathogens. Historically, humans have primarily managed these bacterial tenants through the harsh treatment of antibiotics. But we have consistently observed that as we attempt to eliminate bacteria, they rapidly evolve to survive—promoting the global rise of antibacterial resistance. A potentially more sustainable approach will rely on positively supporting our commensal bacteria residents instead. In order to do this effectively, we must understand their ideal conditions for vibrant growth. Thus far, our team has been investigating how the initial pH of the media influences bacterial growth. We are now poised to study how the bacteria’s mode of growth changes in response to pH, and if a more stable initial pH enhances growth. We are simultaneously excited to compare our findings to that of a pathogen that cohabitates with our commensal bacteria.

Essay prompt: In 1-2 paragraphs, please describe what motivates you to pursue this research opportunity, and work with this research team. Please also comment on why you are interested in performing research full-time over the summer at Mudd.