🍊🍊 Join the C∪TE lab [Santana] 🍊🍊

tl;dr: To apply, complete this form by the URO deadline. Do NOT submit an application through the URO system, these applications will not be reviewed.

The Cell Biology, ufluidics, and Tissue Engineering (C∪TE) lab is hiring undergraduate researchers for the upcoming semester and beyond. Our interdisciplinary team focuses on designing tissue-engineered platforms and microfluidic technologies to understand cell biology and engineer solutions for human health.

As a researcher in the C∪TE lab, you will collaborate across disciplines to develop new tools and advance biological understanding. We are currently recruiting for two main project areas:

1. Extracellular Vesicles (EV) Team

Hiring for Spring + Summer terms

This team investigates cellular function in biomimetic microenvironments to uncover truths about cell-cell communication mediated by extracellular vesicles. Today, we are focusing on material design and imaging. In the future, we aim to control what cells produce by deploying these materials to inform future disease treatments.

  • Core Responsibilities: Design and measure hydrogel properties using a shear rheometer, product viscoelastic and macroporous poly(ethylene glycol) hydrogels, culture glial cells on engineered hydrogel substrates, and collect/examine the cargo of vesicles produced in response to the hydrogels.
  • Bonus: Opportunities to participate in K-12 outreach events related to this work are available based on your interest.

2. Bioprinting & Micromixer Teams

Hiring for Spring term (Summer decisions pending)

This group creates complex tissue models via bioprinting, designing systems capable of producing complex biomaterials. We currently have functioning printers and mixers that handle core functions, and we are looking to expand the printer's capabilities. In the near future, we will print complex, multi-material models and evaluate their performance through mechanical testing and cell studies.

  • Bioprinter Team: Build and evaluate electromechanical systems on a bioprinter for use with photoinitiated hydrogels.

  • Micromixer Team: Build and evaluate microfluidic devices to combine bioinks, and use these models to validate computational fluid dynamics models that optimize device design.

Academic Expectations & E191 Credit

Students participating in research during the academic year will enroll in E191 (Advanced Problems in Engineering) during each term they are on the team. Participating students are encouraged to enroll for 2–3 credits per semester; 1 credit may be considered in limited cases.

Students should budget three hours of lab work per week for each credit, in addition to lab meetings:

  • 1 credit: ≥ 3 hours/week + meetings and training

  • 2 credits: ≥ 6 hours/week + meetings and training

  • 3 credits: ≥ 9 hours/week + meetings and training

C∪TE Lab Open House & Q&A

Want to learn more before applying? Attend our Open House to get acquainted with the work and ask the team your questions.

  • When: DATE || TIME TBD

  • Where: Parsons 2390/2393

How to Apply

To apply, please complete this application form by the URO deadline: Monday, December 7 at 11:55 PM. Do NOT submit an application through the URO system, these applications will not be reviewed.

When completing the application form, be prepared to submit the following materials through the form:

  • Letter of intent

  • Up-to-date CV/resume

  • Unofficial transcript

  • Names and contact information for two references who can comment on your technical abilities and teamwork (especially on collaborative projects).

  • A screen shot of your planned courses for the next semester (e.g. from hyperschedule)

Once you apply, your materials will be reviewed, and selected candidates will be invited to schedule an interview.

Name of research group, project, or lab
C∪TE lab [Santana]
Why join this research group or lab?

The C∪TE lab functions as a dynamic environment of about 20 students from a range of majors and class years because researchers  construct the electromechanical systems, create materials, and create computational fluid dynamics models required to isolate biological mechanisms. Undergraduates build the fundamental tools. The team constructs PID pneumatic pressure controllers to extrude bioinks into FRESH yield-stress baths while concurrently simulating Two-Layer Crossing-Channel Micromixers in ANSYS Fluent to maximize chaotic advection at low Reynolds numbers. This hardware directly enables the critical biological work. By culturing U87MG glioblastoma cells on poly(ethylene glycol) (PEG) hydrogels calibrated to specific Young's moduli, the team extracts vesicles and sequences miRNA cargo to map how physical microenvironments dictate cellular output. Executing these engineering and biological protocols simultaneously prepares researchers to work across disciplines with a focus on human health.

Logistics Information:
Project categories
Biology
Engineering
Physics
Additive Manufacturing
Biomedical Engineering
Biomedical Sciences
Bioprinting
Chemical Engineering
Fluid Mechanics
Materials Science
Mechanical Engineering
Microfluidics
Polymer Science
Student ranks applicable
First-year
Sophomore
Junior
Student qualifications

Participation in the C∪TE lab requires a well-considered approach to troubleshooting rather than extensive prior bench experience. Students must synthesize prior learning and coursework in engineering, physics, biology, and chemistry. We seek researchers who can adapt quickly to complex software and execute precise protocols.

So then, any student who is interested in learning and solving problems in interdisciplinary would be a great fit for the lab.

Time commitment
Spring - Part Time
Summer - Full Time
Compensation
Academic Credit
Paid Research
Number of openings
4
Project start
Spring semester (academic credit). Summer researchers (paid stipend) as described above.
Contact Information:
Mentor
ssantana@hmc.edu
PI
Name of project director or principal investigator
Steven Santana
Email address of project director or principal investigator
ssantana@g.hmc.edu
4 sp. | 0 appl.
Time commitment
Spring - Part Time (+1)
Spring - Part TimeSummer - Full Time
Project categories
Chemical Engineering (+12)
BiologyEngineeringPhysicsAdditive ManufacturingBiomedical EngineeringBiomedical SciencesBioprintingChemical EngineeringFluid MechanicsMaterials ScienceMechanical EngineeringMicrofluidicsPolymer Science