Rotational Spectroscopy of Anticonvulsant Drugs
Rotational spectroscopy allows for full molecular characterization. However, in order to achieve this, it is necessary to record the rotational spectra of both the parent molecule and a family of molecules that have the same molecular structure but have been substituted with less common isotopes. For example, substitution of 13C for 12C at a particular position in the molecular structure can provide an additional data set to pin down the atomic position with remarkable precision. These isotopically substituted molecules are rarely commercially available though. So, Prof. HC and Prof. Brucks have engaged a collaboration to enable students to develop procedures to synthesize isotopically labelled molecules that are then analyzed by Microwave Spectroscopy. This summer we will focus on the synthesis and characterization of succinmide derivatives that are commonly used as anticonvulsant drugs, though the complete three-dimensional molecular structure is unknown.
If you join this project you will gain expertise in a versatile set of skills. You will be part have the unique opportunity to do exciting research that bridges synthetic chemistry and molecular spectroscopy!
Logistics: You will be actively working in either Prof HC's or Prof Bruck's lab full-time for 10 weeks from Monday June 2nd to Friday, August 8 (June 19 and July 4 are holidays). The typical commitment is ~40 hours per week with an approximate schedule of 9 am - 6 pm per day. You will have group meeting with both groups for research updates.
Essay prompt: In 1 page please describe what motivates you to pursue this full-time summer research opportunity.
This is a relatively new collaboration between two groups and you will have the opportunity to help explore new directions. This specific project will afford experience in techniques from both organic chemistry and physical chemistry and it will reflective on how academic and industry groups work. You will have the opportunity to learn various characterization techniques from common organic ones such as NMR and chromatography, to doing actual molecular spectroscopy on your own synthesized products. Both labs strongly emphasize in having an environment that fosters respect and inclusivity so that everyone can succeed.